Abstract This work aimed on assessing the viability of an isogrid structural reinforcement in the fuselage of a Boeing 737. The failure mode under consideration was compressive buckling – an instability which caused sudden failure due to structural changes under compressive loading. Literature proved that varying isogrid geometrical parameters varied stiffness – an outcome useful for resisting buckling. The first analysis proved this and verified finite element analysis SHELL modelling in its ability to represent isogrid stiffness. The results agreed with theoretical stiffness increases obtained from the Isogrid Design Handbook – and so the modelling techniques used in Finite Element Analysis software, Ansys, were deemed sufficient in capturing behaviour of isogrids. A secondary analysis was conducted which utilised the modelling techniques from Analysis 1 to represent a Boeing 737 fuselage panel with stringer stiffening. The stiffnesses gathered from this analysis were used with calculations from the Isogrid Design Handbook to create an Isogrid replacement to the panel. Buckling analysis was performed on both specimen, which displayed increases of buckling load to the isogrid when compared with the current fuselage design. However, the isogrid replacement was overweight and so was not a viable replacement to the current uni-directional stiffening systems. It was gathered that the isogrid was overweight due to its multi-directional stiffening. In comparison to the current uni-directional stringers, the isogrid was able to resist loading almost equally in all directions. This made the isogrid effective under torsion. The uni-directional stiffeners were weaker under torsion. A final analysis was conducted, assessing the effect of isogrid stiffening on the skin of the fuselage to prevent skin instability. The isogrid was deemed more effective in increasing the buckling load whilst minimizing weight for a multi-directional stiffening system. These results displayed the capability of isogrid to reinforce specific areas of compressive buckling failure.